Tokyo stocks opened mixed on Thursday as the yen's appreciation against the U.S. dollar following a U.S. Federal Reserve policy meeting inhibited buying to some extent, although hopes for more robust corporate earnings minimized selling.

As of 9:15 a.m., the 225-issue Nikkei Stock Average lost 19.94 points, or 0.10 percent, from Wednesday to 20,030.22.

The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, gained 1.24 points, or 0.08 percent, at 1,622.12.

Issues that notably declined in early trade comprised bank and insurance-linked stocks, while food and real estate issues led those that gained.